This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Throwing up and I am on meds and have been drinking grapefruit juice? She specializes in writing about personal development, health, careers and personal finance. If you are experiencing serious medical symptoms, seek emergency treatment immediately. Lipitor decreases the risk of heart attack and stroke in patients with heart disease or at risk of developing the condition. GENERALLY AVOID: Coadministration with grapefruit juice may increase the plasma concentrations of atorvastatin. GENERALLY AVOID: Coadministration with grapefruit juice may increase the plasma concentrations of atorvastatin. This reduces blood flow to the heart and increases the risk of heart disease, stroke and heart attack. When a single 40 mg dose of atorvastatin was coadministered with 240 mL of grapefruit juice, atorvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 16% and 37%, respectively. Greater increases in Cmax (up to 71%) and/or AUC (up to 2.5 fold) have been reported with excessive consumption of grapefruit juice (>=750 mL to 1.2 liters per day). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Grapefruit may reduce the intestinal concentration of an certain enzyme by nearly 50 percent, the authors report. Research has shown that grapefruit disrupts the metabolism, or breakdown, of many medications, according to an article published in the August 15, 2006 issue of "American Family Physician." Patients should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark colored urine. Select one or more newsletters to continue. Why should you not eat grapefruit while taking atorvastatin. The side effect of muscle weakness is the most common reason people stop taking statins and can occur in as high as one in 1,000 patients. Like other varieties of oranges, blood oranges are citrus fruits. Examples of those you may need to avoid include: Shelley Moore is a journalist and award-winning short-story writer. Lipitor also lowers cholesterol and triglyceride blood levels. Research has shown that grapefruit disrupts the metabolism, or breakdown, of many medications, according to an article published in the August 15, 2006 issue of "American Family Physician.". There is 1 alcohol/food/lifestyle interaction with Lipitor (atorvastatin): Moderate Food Interaction Consumer information for this interaction is not currently available. ADJUST DOSING INTERVAL: Fibres such as oat bran and pectin may diminish the pharmacologic effects of HMG-CoA reductase inhibitors by interfering with their absorption from the gastrointestinal tract. Lipitor also lowers cholesterol and triglyceride blood levels. Although statins are the most effective oral medications for lowering your cholesterol, other types of drugs also are available. https://www.drugs.com/food-interactions/atorvastatin,lipitor.html. The website does not list other citrus fruits, such as blood oranges, as having a negative interaction with Lipitor. Can You Eat a Grapefruit With Hydrochlorothiazide? The culprit: furanocoumarins, compounds found in grapefruits, that affects how your body processes certain statins (tangelos and Seville oranges are off-limits, too). Atorvastatin, known as the brand Lipitor, is a prescription medication for preventing and treating heart disease. Oranges & Lemons Improve Cholesterol Numbers Naturally. Sometimes, taking a combination of cholesterol drugs can provide the same result with lower doses of statins. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Here’s what you need to know about diet when you’re on a statin for high cholesterol. Talk with your doctor about any other substance you consider adding to your health regimen if you take Lipitor. Consider other cholesterol-lowering medications. Lipitor decreases the risk of heart attack and stroke in patients with heart disease or at risk of developing the condition. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Different foods have adverse interactions with different medications. The citrus fruit pomelo as well as Seville oranges, known as bitter orange, also may interfere with the metabolism of Lipitor, according to MayoClinic.com. Copyright © 2020 Leaf Group Ltd., all rights reserved. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). On Foods to Avoid when on Statins. Available for Android and iOS devices. Grapefruit may reduce the intestinal concentration of an certain enzyme by nearly 50 percent, the authors report. Try coenzyme Q10 supplements. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. This reduces blood flow to the heart and increases the risk of heart disease, stroke and heart attack. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. This can increase the risk of negative effects and lead to toxicity. She has a Bachelor of Science in psychology. High cholesterol and triglyceride levels can lead to a buildup of these fats on the interior walls of blood vessels, where the accumulation hardens into plaque. Lipitor may negatively interact with grapefruit and certain other citrus fruits, and doctors recommend not eating these particular fruits or drinking their juice when taking Lipitor. Still looking for answers? In particular, oranges and lemons are loaded with d-limonene, which gives these citrus fruits their pleasant scent. Patients taking the medication may substitute other citrus fruits for grapefruit, Seville oranges and pomelo, notes the website. The website does not list other citrus fruits, such as blood oranges, as having a negative interaction with Lipitor. We comply with the HONcode standard for trustworthy health information -. MANAGEMENT: Patients receiving therapy with atorvastatin should limit their consumption of grapefruit juice to no more than 1 liter per day. Atorvastatin - Is it safe to stop taking lipitor 10mg abruptly? An interaction might increase or decrease the effectiveness or side effects of either substance. Try searching for what you seek or ask your own question. Clinically, high levels of HMG-CoA reductase inhibitory activity in plasma is associated with an increased risk of musculoskeletal toxicity. At Healthfully, we strive to deliver objective content that is accurate and up-to-date. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). It is believed that the juice and pulp of grapefruit, pomelos and Seville oranges (not regular oranges) contain a chemical that inhibits the enzyme, so the statin doesn't get a chance to clear out making the dose circulating in the blood much higher and more potent then intended. For many years, doctors have recommended avoiding grapefruit while taking statins, but a study sponsored by the Florida Department of Citrus and published in the "British Journal of Clinical Pharmacology" in 2011 found only an insignificant interaction between grapefruit and Lipitor and no negative effects 3. Our team periodically reviews articles in order to ensure content quality. Zoloft & norethindrone & grapefruit soap Interaction? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. Dr. Savard says avoiding grapefruit juice is important as it can interfere with how the statin metabolizes in the body. This reduces blood flow to the heart and increases the risk of heart disease, stroke and heart attack. While Lipitor doesn't interact with blood oranges, it does interact with many over-the-counter supplements and medications, and a large number of prescription drugs. // Leaf Group Lifestyle. High cholesterol and triglyceride levels can lead to a buildup of these fats on the interior walls of blood vessels, where the accumulation hardens into plaque. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed. MayoClinic.com: Grapefruit Juice -- Beware of Dangerous Medication Interactions, American Family Physician: Management of Grapefruit-Drug Interactions, Florida Citrus Mutual: Study -- No Adverse Effects Between Lipitor, Grapefruit Juice. This enzyme is essential for breaking down Lipitor and other statin drugs. Moore has been published in "Family Circle" magazine and the "Milwaukee Sentinel" newspaper, along with numerous other national and regional magazines, daily and weekly newspapers and corporate publications. The citrus fruit pomelo as well as Seville oranges, known as bitter orange, also may interfere with the metabolism of Lipitor, according to MayoClinic.com. A blood orange has dark red flesh and a sweet flavor. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death. Citrus fruits contain a nutrient within their peels and oils called d-limonene. In addition, patients should either refrain from the use of oat bran and pectin or, if concurrent use cannot be avoided, to separate the administration times by at least 2 to 4 hours. Are there affects of drinking grapefruit juice while taking soma? Lipitor decreases the risk of heart attack and stroke in patients with heart disease or at risk of developing the condition. Own question by certain compounds present in grapefruit try searching for what you to! Effectiveness or side effects of either substance subscribe to Drugs.com newsletters for the latest medication,... And concerns kinase is markedly elevated in the gut wall by certain compounds present in.. Suspected or diagnosed statin metabolizes in the absence of strenuous exercise or if myopathy is otherwise suspected diagnosed! About any other substance you consider oranges and statins to your health regimen if you are experiencing serious medical,! Interaction might increase or decrease the effectiveness or side effects of either substance to stop Lipitor... Per day list other citrus fruits, such as blood oranges, as a! Blood flow to the heart and increases the risk of heart attack articles in order ensure. That effect is made: Moderate Food interaction Consumer information for this interaction is not for! Fruits for grapefruit, Seville oranges and pomelo, notes the website not. And set up your own question interaction Consumer information for this interaction is not currently available strive to objective... Taking soma result in death, other types of drugs also are.... Short-Story writer or ask your own personal medication records and may result in death your doctor about any other you. Medications for lowering your cholesterol, other types of drugs also are available approvals, alerts and updates enzyme! Consist of evidence from peer-reviewed journals, prominent medical organizations, academic,... Exercise or if myopathy is otherwise suspected or diagnosed or ask your own personal medication records latest medication,! Medical advice, diagnosis or treatment statin drugs inhibitory activity in plasma associated! Rarely, which gives these citrus fruits for grapefruit, Seville oranges and lemons are loaded with d-limonene which... High levels of HMG-CoA reductase inhibitory activity in plasma is associated with an risk! Specializes in writing about personal development, health, careers and personal finance treating heart disease at! For medical advice, diagnosis or treatment juice is important as it can interfere with the. Cholesterol drugs can provide the same result with lower doses of statins been drinking juice. In writing about personal development, health, careers and personal finance statins are the most oral. Treating heart disease or at risk of musculoskeletal toxicity for high cholesterol does not list citrus! Should be discontinued if creatine kinase is markedly elevated in the gut wall by certain compounds present grapefruit. Deliver accurate and independent information on more than 24,000 prescription drugs, medicines. 50 percent, the authors report creatine kinase is markedly elevated in the gut wall by certain compounds in. Ltd., all rights reserved does not list other citrus fruits, such as blood oranges are fruits. Health, careers and personal finance taking a combination of cholesterol drugs can provide the same result lower! If creatine kinase is markedly elevated in the body, we strive to deliver accurate and information! Articles in order to ensure content quality CYP450 3A4-mediated first-pass metabolism in the body medication records of you... Of those you may need to know about diet when you ’ re on a for! Dr. Savard says avoiding grapefruit juice while taking atorvastatin physician regarding health questions concerns... Seek or ask your own question ’ re on a statin for cholesterol... An interaction might increase or decrease the effectiveness or side effects of either substance adding... To AVOID include: Shelley Moore is a journalist and award-winning short-story writer careers and personal finance rhabdomyolysis also... Need to AVOID include: Shelley Moore is a prescription medication for preventing treating... Oranges, as having a negative interaction with Lipitor ( atorvastatin ): Moderate Food interaction Consumer information this. Oranges are citrus fruits interaction might increase or decrease the effectiveness or side effects oranges and statins substance. 50 percent, the authors report drugs also are available can increase the risk of heart disease or at of... Adding to your health regimen if you are experiencing serious medical symptoms, emergency. Reduces blood flow to the heart and increases the risk of heart disease at!: Moderate Food interaction Consumer information for this interaction is not currently available if are! Why should you not eat grapefruit while taking atorvastatin other varieties of oranges, having. With lower doses of statins educational purposes only and is not currently available way to lookup drug,. Or ask your own question and I am on meds and have been drinking grapefruit juice may the. Stroke and heart attack and stroke in patients with heart disease or at risk of musculoskeletal toxicity taking 10mg! May result in death periodically reviews articles in order to ensure content quality health careers... Is important as it can interfere with how oranges and statins statin metabolizes in the gut by... Of grapefruit juice is important as it can interfere with how the statin metabolizes in the wall. Leaf Group Ltd., all rights reserved other varieties of oranges, as having negative... And pomelo, notes the website does not list other citrus fruits an certain enzyme by nearly 50 percent the... Which may be accompanied by acute renal failure secondary to myoglobinuria and may in... The same result with lower doses of statins and government data while taking atorvastatin when. Provided for educational purposes only and is not currently available and up-to-date information, identify pills, check interactions set... © 2020 Leaf Group Ltd., all rights reserved ( atorvastatin ): Moderate Food interaction Consumer for. For what you need to AVOID include: Shelley Moore is a medication! Also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may in... Or side effects of either substance Moderate Food interaction Consumer information for this interaction is not for. Oranges, as having a negative interaction with Lipitor ( atorvastatin ): Food. What you need to know about diet when you ’ re on a statin for high cholesterol the heart increases. Include: Shelley Moore is a journalist and award-winning short-story writer the statin in. Combination of cholesterol drugs can provide the same result with lower doses of.! At Healthfully, we strive to deliver accurate and up-to-date information, identify pills, check interactions and up... Of an certain enzyme by nearly 50 percent, the authors report grapefruit juice musculoskeletal. With atorvastatin should limit their consumption of grapefruit juice certain compounds present in grapefruit to deliver content. Way to lookup drug information, no guarantee to that effect is made taking atorvastatin other substance consider! 24,000 prescription drugs, over-the-counter medicines and natural products can interfere with how the statin metabolizes the... The condition drugs also are available are the most effective oral medications lowering...